HRID366071

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

反应SMILES：COc1ccc([C@H](CO)NC(=O)[C@@H](CCCNC(=O)OCc2ccccc2)NC(=O)C(c2ccccc2)c2ccccc2)cc1

HCID131722078

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc([C@H](CO)NC(=O)[C@@H](CCCN)NC(=O)C(c2ccccc2)c2ccccc2)cc1.Cl

HCID131722079

(R)-N2-(Diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-ornithine amide hydrochloride

C28H34ClN3O4

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]ornithine amide (0.63 g; from step (c) above), 10% Pd/C (0.30 g), MeOH (100 mL) and concentrated HCl (1 mL) under hydrogen, 18 hours reaction time to give the crude sub-title compound as a solid (0.57 g) which was used without purification.

WORKUP

后处理

customPrepared
customreaction time

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-971e0f117d4a45b0b6a6652b5da58681
来源数据集: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06127414
来源说明: uspto-grants-2000_10

反应SMILES

C([NH:11][CH2:12][CH2:13][CH2:14][C@H:15]([C:32]([NH:34][C@H:35]([C:38]1[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=1)[CH2:36][OH:37])=[O:33])[NH:16][C:17](=[O:31])[CH:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)(OCC1C=CC=CC=1)=O.[ClH:46]>[Pd].CO>[ClH:46].[C:19]1([CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:17]([NH:16][C@@H:15]([C:32]([NH:34][C@H:35]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=2)[CH2:36][OH:37])=[O:33])[CH2:14][CH2:13][CH2:12][NH2:11])=[O:31])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1