Hydrogen chloride-ethyl acetate → HCID 178462157, compound

Participants

Reaction Steps

A solution of (R)-Nω,Nω '-bis(Cbz)-N2 -(Boc)-(R)-N-[1-(4-hydroxyphenyl)-ethyl]arginine amide (11.2 g; 16.4 mmol, from step (b) above) in EtOAc (300 mL) was treated with HCl/EtOAc (300 mL) and stirred overnight at room temperature. The product precipitated as a white residue from which the solvents were decanted. To the residue was added methanol (100 mL) followed by diethyl ether (50 mL). This mixture was slurried and then concentrated at reduced pressure to afford the sub-title compound as a white crushable foam (10.2 g; 100%).

Provenance & Evidence