反应详情

A solution of (R)-Nω,Nω '-bis(Cbz)-N2 -(Boc)-(R)-N-[1-(4-hydroxyphenyl)-ethyl]arginine amide (11.2 g; 16.4 mmol, from step (b) above) in EtOAc (300 mL) was treated with HCl/EtOAc (300 mL) and stirred overnight at room temperature. The product precipitated as a white residue from which the solvents were decanted. To the residue was added methanol (100 mL) followed by diethyl ether (50 mL). This mixture was slurried and then concentrated at reduced pressure to afford the sub-title compound as a white crushable foam (10.2 g; 100%).

1. customThe product precipitated as a white residue from which the solvents
2. customwere decanted
3. additionTo the residue was added methanol (100 mL)
4. concentrationconcentrated at reduced pressure