反应详情

温度

220 °C

A mixture of 6-methylquinoline (5.72 g, 40.0 mmol) and selenium oxide (4.44 g, 40.0 mmol) was heated to 220° C. for 1 h. After cooling down the residue was dissolved in ethyl acetate (100 mL). The organic solution was washed with brine, dried over MgSO4. Evaporation of solvents provided a solid, which was recrystalized from ether-hexane (1:1) mixture to give 6-quinolinecarboxaldehyde (3.45 g, 55%).

1. temperatureAfter cooling down the residue
2. washThe organic solution was washed with brine
3. dry with materialdried over MgSO4
4. customEvaporation of solvents
5. customprovided a solid, which
6. customwas recrystalized from ether-hexane (1:1) mixture