HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester | HCID 9802915 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(3,4-Methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d-]pyrimidin-2-yl]-benzoic acid | HCID 9888324 | 70.5% |
Reaction Steps
A solution of 1.1 g of methyl 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoate, 30 ml of 2N NaOH and 30 ml of tetrahydrofuran is heated at 100° for 6 hours. After cooling and acidification of the solution with 20% HCl, the mixture is further worked up in the customary manner. 0.75 g of 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid is obtained, m.p. >250°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130223 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-099980c9907e46318237a255103072a7 |
| Source note | uspto-grants-2000_10 |