反应详情

A solution of 1.1 g of methyl 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoate, 30 ml of 2N NaOH and 30 ml of tetrahydrofuran is heated at 100° for 6 hours. After cooling and acidification of the solution with 20% HCl, the mixture is further worked up in the customary manner. 0.75 g of 4-[4-(3,4-methylenedioxybenzylamino)-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid is obtained, m.p. >250°.

1. temperatureAfter cooling