2-Fluoroaniline → HCID 70257028, compound

HRID 366390Notes

Reaction equation

HRID 366390 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].O=[C:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]#[N:16].[Cl-].[Ca+2].[Cl-]>>[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10]1[CH2:14][CH2:13][CH2:12][C:11]=1[C:15]#[N:16]

Participants

4

Reactant 3

HCID 95842-FluoroanilineHCID 98930Cyclopentanecarbonitrile, 2-oxo-HCID 5284359Calcium Chloride

Product 1

HCID 70257028HCID 70257028, compound

Procedure

2-Fluoro-aniline (Aldrich Chemicals) (2.3 g, 21 mmol), cyanoketone (Example 11) (2.2 g, 20 mmol), calcium chloride (2.5 g, 23 mmol) and T.H.F. (30 ml) were heated under reflux for 24 hours. After being allowed to cool, the mixture was filtered and the solvent evaporated. Kugelrohr distillation (125° C. 0.05 mm Hg) have the product as an off-white power.

Workup

  1. temperature(30 ml) were heated
  2. temperatureunder reflux for 24 hours
  3. temperatureto cool
  4. filtrationthe mixture was filtered
  5. customthe solvent evaporated
  6. distillationKugelrohr distillation (125° C. 0.05 mm Hg)

Sources & evidence

ORD record
ord-a044fa71a9914880ad30ca2c8a233a47
Source dataset
uspto-grants-2000_10
Patent number
US06130228

Reaction notes

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