참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Methanethioamide | HCID 3005587 | — |
| 반응물 | o-(Bromoacetyl)phenyl acetate | HCID 12956296 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-(1,3-Thiazol-4-yl)phenol | HCID 4396098 | — |
반응 단계
o-(Bromoacetyl)phenyl acetate (5.0 g, 19.5 mmol) was treated with crude thioformamide (filtrate concentrated in vacuo from reaction of P2S5 (1.1 eq.) and (25 mmol) formamide in THF (30-40° C., 5 hours)) in refluxing acetone (60 mL). After 16 hours the reaction mixture was cooled to about 10° C. and the precipitated HBr salt of 2-(thiazol-4-yl)phenol was recovered. 31%, 1.50 g, LSIMS m/z=178 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06130217 |
|---|
| 출처 데이터셋 | uspto-grants-2000_10 |
|---|
| ORD ID | ord-fd56c51420604825a63587795cc7eb8b |
|---|
| 출처 메모 | uspto-grants-2000_10 |
|---|
