Formamide → 2-(1,3-Thiazol-4-yl)phenol

HRID 366437노트

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HRID 366437 반응식
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=O)[CH2:12]Br)(=O)C.[CH:15]([NH2:17])=[S:16].C(N)=O>CC(C)=O>[S:16]1[CH:12]=[C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])[N:17]=[CH:15]1

참가 물질

5

반응물 3

HCID 713FormamideHCID 3005587MethanethioamideHCID 12956296o-(Bromoacetyl)phenyl acetate

생성물 1

HCID 43960982-(1,3-Thiazol-4-yl)phenol

시약·촉매·용매 1

HCID 180Acetone용매

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온도
10 °C

실험 절차

o-(Bromoacetyl)phenyl acetate (5.0 g, 19.5 mmol) was treated with crude thioformamide (filtrate concentrated in vacuo from reaction of P2S5 (1.1 eq.) and (25 mmol) formamide in THF (30-40° C., 5 hours)) in refluxing acetone (60 mL). After 16 hours the reaction mixture was cooled to about 10° C. and the precipitated HBr salt of 2-(thiazol-4-yl)phenol was recovered. 31%, 1.50 g, LSIMS m/z=178 (MH+).

후처리

  1. customthe precipitated HBr salt of 2-(thiazol-4-yl)phenol was recovered

출처 및 근거

ORD 기록
ord-fd56c51420604825a63587795cc7eb8b
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130217

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