Imidazole → HCID 23289325, compound

HRID 366442Notes

Reaction equation

HRID 366442 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH2:9]O>O>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:9][C:8]1[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=1[OH:6]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 5146Salicyl Alcohol

Product 1

HCID 23289325HCID 23289325, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

A mechanical mixture of imidazole (5 eq., 3.5 g) and 2-hydroxybenzyl alcohol (1.0 eq., 1.24 g) was heated to about 120° C. in a stoppered flask. The melt was stirred for 5 hours at about 120° C., allowed to cool and the fused mass was treated with hot H2O (40 mL) and the resulting suspension was cooled to about 4° C. The white crystalline precipitate was filtered and dried in vacuo to constant mass (1.49 g, 85%; LSIMS m/z 175 (MH+)).

Workup

  1. temperatureto cool
  2. temperaturethe resulting suspension was cooled to about 4° C
  3. filtrationThe white crystalline precipitate was filtered
  4. customdried in vacuo to constant mass (1.49 g, 85%; LSIMS m/z 175 (MH+))

Sources & evidence

ORD record
ord-077d5aee71ee4efcaf7e808b63cb24b5
Source dataset
uspto-grants-2000_10
Patent number
US06130217

Reaction notes

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