Imidazole → HCID 23289325, compound

Participants

Reaction Conditions

Reaction Steps

A mechanical mixture of imidazole (5 eq., 3.5 g) and 2-hydroxybenzyl alcohol (1.0 eq., 1.24 g) was heated to about 120° C. in a stoppered flask. The melt was stirred for 5 hours at about 120° C., allowed to cool and the fused mass was treated with hot H2O (40 mL) and the resulting suspension was cooled to about 4° C. The white crystalline precipitate was filtered and dried in vacuo to constant mass (1.49 g, 85%; LSIMS m/z 175 (MH+)).

Provenance & Evidence