Acetyl chloride → 3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenol

HRID 366452Notes

Reaction equation

HRID 366452 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](=[N:7][OH:8])[NH2:6].[C:12](Cl)(=O)[CH3:13]>N1C=CC=CC=1>[CH3:12][C:13]1[O:8][N:7]=[C:5]([C:4]2[CH:3]=[C:2]([OH:1])[CH:11]=[CH:10][CH:9]=2)[N:6]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 54381771N,3-dihydroxybenzenecarboximidamide

Product 1

HCID 120425193-(5-Methyl-1,2,4-oxadiazol-3-yl)phenol

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenol was prepared using 3-hydroxybenzamidoxime (1 g, 6.6 mM) and acetyl chloride (0.52 g, 6.7 mM) in pyridine (4 mL) according to Preparation 62 to provide 0.66 g of a white powder; m.p., 87-89° C.

Workup

  1. customaccording to Preparation 62

Sources & evidence

ORD record
ord-52fd1baa4a134488b0659cbab78f36d9
Source dataset
uspto-grants-2000_10
Patent number
US06130217

Reaction notes

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