3-[5-(3-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine → HCID 23289232, compound

HRID 366454Notes

Reaction equation

HRID 366454 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][N:12]=[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[N:10]=2)[CH:6]=[CH:7][CH:8]=1.Cl.N1C=CC=CC=1>O>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:11]2[N:10]=[C:9]([C:5]3[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=3)[O:13][N:12]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 7898583-[5-(3-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridineHCID 10176127Pyridinium chloride

Product 1

HCID 23289232HCID 23289232, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-[5-(3-Methoxyphenyl)-[1,2,4]oxadiazol-3-yl)pyridine (4.0 g, 15.79 mM) and pyridine hydrochloride (37.6 g, 325 mM) were melted together at about 160° C. under an atmosphere of nitrogen for about 30 hours. This mixture was poured into H2O and stirred. The precipitated product was filtered and dried, 2.9 g, mp. >200° C.

Workup

  1. filtrationThe precipitated product was filtered
  2. customdried

Sources & evidence

ORD record
ord-5f31d29052804a36bc3c0b6fae16b13b
Source dataset
uspto-grants-2000_10
Patent number
US06130217

Reaction notes

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