Acetic Acid → HCID 22448959, compound

HRID 366456Notes

Reaction equation

HRID 366456 reaction equation
[OH:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:14](O)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 99422906-Hydroxy-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Product 1

HCID 22448959HCID 22448959, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 1,3,4,5-tetrahydro-6-hydroxy-2H-1-benzazepin-2-one (500 mg, 2.82 mmol) in 2.5 mL each of pyridine and acetic acid was stirred at room temperature. Excess reagents were removed under reduced pressure and the residue was triturated with CH2Cl2 to give 540 mg (87%) of 1,3,4,5-tetrahydro-6-acetoxy-2H-1-benzazepin-2-one; MS 219.

Workup

  1. customExcess reagents were removed under reduced pressure
  2. customthe residue was triturated with CH2Cl2

Sources & evidence

ORD record
ord-70c2dc89be7249f8a3520f32da86a2e0
Source dataset
uspto-grants-2000_10
Patent number
US06130217

Reaction notes

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