HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (1-Azidocyclohexyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 1-Phenyl-1-cyclopentanol | HCID 139165 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (1-Azidocyclohexyl)benzene | HCID 2769487 | 92.4% |
Reaction Steps
1-Phenylcyclopentanol (16.3 g, 100 mmol) was treated with NaN3 (s) (20 g, 310 mmol) and TFA (65 g) in CHCl3 (170 mL) at about 0-5° C., according to the procedure described in Preparation 87, to produce crude 1-phenyl-cyclohexylazide (18.6 g, GC-MS m/z 187).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130217 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-5ed29fe2d96b4568ac18eafc9744bbea |
| Source note | uspto-grants-2000_10 |