HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyloxycarbonyl-4-[5-cyano-1-(2-trimethylsilylethanesulfonyl)indol-3-yl]piperidine → 4-[5-Cyano-1-(2-trimethylsilyl-ethanesulfonyl)indol-3-yl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyloxycarbonyl-4-[5-cyano-1-(2-trimethylsilylethanesulfonyl)indol-3-yl]piperidine | HCID 22615554 | — |
| Reactant | 5-fluoro-3-(1-tert-butoxycarbonylpiperidin-4-yl)-1H-indole | HCID 22714417 | — |
| Product | 4-[5-Cyano-1-(2-trimethylsilyl-ethanesulfonyl)indol-3-yl]piperidine | HCID 22615721 | — |
Reaction Steps
Proceeding as described in Example 19, Step 3, but substituting 1-benzyloxycarbonyl-4-(5-cyano-1-methanesulfonylindol-3-yl)piperidine with 1-benzyloxycarbonyl-4-[5-cyano-1-(2-trimethylsilylethanesulfonyl)indol-3-yl]piperidine (prepared as described in Example 14, Step 2, by substituting 1-benzyloxycarbonyl-4-(5-cyanoindol-3-yl)piperidine for N-tert-butoxycarbonyl-4-(5-fluoroindol-3-yl)piperidine] gave 4-[5-cyano-1-(2-trimethylsilyl-ethanesulfonyl)indol-3-yl]piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130220 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-071e28238a8041ae80ac9ebf4824f694 |
| Source note | uspto-grants-2000_10 |