反应详情

温度

90 °C

Potassium cyanide (2.0 g) was added to 15 mL of dimethylsulfoxide and heated to 90° C. 5-Chloroethyl-2-oxindole (3.0 g) dissolved in 5 mL dimethyl sulfoxide was added slowly with stirring, and the reaction heated to 150° C. for 2 hours. The mixture was cooled, poured into ice water and the precipitate collected by vacuum filtration, washed with water, dried and then chromatographed on silica gel (5% methanol in chloroform) to give 1.2 g (42% yield) of the title compound.

1. additionwas added slowly
2. temperaturethe reaction heated to 150° C. for 2 hours
3. temperatureThe mixture was cooled
4. filtrationthe precipitate collected by vacuum filtration
5. washwashed with water
6. customdried
7. customchromatographed on silica gel (5% methanol in chloroform)