Hydrochloric Acid → 4-Methyloctahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride

Participants

Reaction Steps

A solution of 9.4 g (40 mmol) of 8-benzyl-5-methyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 150 ml of methanol and 7.4 ml of concentrated hydrochloric acid is hydrogenated on 3 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated. The residue is triturated with butanol/acetone 1:1 and the crystals are filtered off with suction and dried over P4O10 in a desiccator. The product is very hygroscopic.

Provenance & Evidence