反应详情

A solution of 9.4 g (40 mmol) of 8-benzyl-5-methyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 150 ml of methanol and 7.4 ml of concentrated hydrochloric acid is hydrogenated on 3 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated. The residue is triturated with butanol/acetone 1:1 and the crystals are filtered off with suction and dried over P4O10 in a desiccator. The product is very hygroscopic.

1. filtrationThe catalyst is filtered off with suction
2. concentrationthe filtrate is concentrated
3. customThe residue is triturated with butanol/acetone 1:1
4. filtrationthe crystals are filtered off with suction
5. dry with materialdried over P4O10 in a desiccator