反应详情

190.5g (0.8 mol) of pyridine-2,3-dicarboxylic acid N-benzylimide are dissolved in 800 ml of nitromethane, while heating, and 136 g (0.96 mol) of methyl iodide are added dropwise. The mixture is then boiled for 8 hours while cooling under reflux (cooling water 0° C.). After cooling, the solid is filtered off with suction and washed with methylene chloride. 123 g of dark red crystals having a melting point of 162°-165° C. (decomposition) are obtained.

1. temperaturewhile heating
2. temperaturewhile cooling
3. temperatureunder reflux
4. temperatureAfter cooling
5. filtrationthe solid is filtered off with suction
6. washwashed with methylene chloride
7. customare obtained