6-Benzyl-1-methyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridine → 6-Benzyl-1-methyloctahydropyrrolo[3,4-b]pyridine

HRID 36675Notes

Reaction equation

HRID 36675 reaction equation
[CH2:1]([N:8]1[C:16](=O)[CH:15]2[CH:10]([N:11]([CH3:18])[CH2:12][CH2:13][CH2:14]2)[C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH3:18])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 150700076-Benzyl-1-methyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridineHCID 21226445Aluminium lithium hydride

Product 1

HCID 150700086-Benzyl-1-methyloctahydropyrrolo[3,4-b]pyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

19.2 g (0.08 mol) of crude 6-benzyl-1-methyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridine are reduced with 6.1 g (0.16 mol) of lithium aluminum hydride in absolute tetrahydrofuran in accordance with the working instructions of Example 1c.

Sources & evidence

ORD record
ord-20f96d7a019c4e0ea314e8f3b0dc4f36
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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