(4-Pyridylthio)acetic acid → 4-(8-Chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-1-[(4-pyridinyl-thio)acetyl]piperazine

HRID 366787Notes

Reaction equation

HRID 366787 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH:6]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:7]3[C:12]([CH2:13][S:14][C:4]=2[CH:3]=1)=[CH:11][CH:10]=[CH:9][N:8]=3.[N:23]1[CH:28]=[CH:27][C:26]([S:29][CH2:30][C:31](O)=[O:32])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH:6]([N:15]3[CH2:16][CH2:17][N:18]([C:31](=[O:32])[CH2:30][S:29][C:26]4[CH:27]=[CH:28][N:23]=[CH:24][CH:25]=4)[CH2:19][CH2:20]3)[C:7]3[C:12]([CH2:13][S:14][C:4]=2[CH:3]=1)=[CH:11][CH:10]=[CH:9][N:8]=3

Participants

3

Reactant 2

HCID 82574(4-Pyridylthio)acetic acidHCID 157805018-Chloro-5,11-dihydro-11-(1-piperazinyl)[1]benzothiepino[4,3-b]pyridine

Product 1

HCID 232898634-(8-Chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-1-[(4-pyridinyl-thio)acetyl]piperazineYield 94%

Procedure

The title compound (548 mg, 94%) [MS (FAB, M+H)=483.1] was prepared similarly from 1-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-piperazine (400 mg, 1.21 mmol) and (4-pyridinylthio)acetic acid (410 mg, 2.42 mmol).

Sources & evidence

ORD record
ord-488157d7c74d4bae8b4cff824aa01612
Source dataset
uspto-grants-2000_10
Patent number
US06130229

Reaction notes

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