HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Pyridylthio)acetic acid → 4-(8-Chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-1-[(4-pyridinyl-thio)acetyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Pyridylthio)acetic acid | HCID 82574 | — |
| Reactant | 8-Chloro-5,11-dihydro-11-(1-piperazinyl)[1]benzothiepino[4,3-b]pyridine | HCID 15780501 | — |
| Product | 4-(8-Chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-1-[(4-pyridinyl-thio)acetyl]piperazine | HCID 23289863 | 94% |
Reaction Steps
The title compound (548 mg, 94%) [MS (FAB, M+H)=483.1] was prepared similarly from 1-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-piperazine (400 mg, 1.21 mmol) and (4-pyridinylthio)acetic acid (410 mg, 2.42 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06130229 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-488157d7c74d4bae8b4cff824aa01612 |
| Source note | uspto-grants-2000_10 |