HCID 23286787, compound → 3-(Piperazin-1-yl)-1-azabicyclo[2.2.2]octane

HRID 366959Notes

Reaction equation

HRID 366959 reaction equation
C(O[N:9]1[CH2:14][CH2:13][N:12]([CH:15]2[CH:20]3[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]3)[CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[N:17]12[CH2:18][CH2:19][CH:20]([CH2:21][CH2:22]1)[CH:15]([N:12]1[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)[CH2:16]2

Participants

4

Reactant 1

HCID 23286787HCID 23286787, compound

Product 1

HCID 221202283-(Piperazin-1-yl)-1-azabicyclo[2.2.2]octaneYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-benzyloxy-4-(3-quinuclidinyl)piperazine (728 mg, 2.21 mmol) in methanol (5 ml). was hydrogenated at an atmospheric pressure in the presence of 10% palladium on carbon (73 mg) at room temperature for 15 h. The mixture was then filtered through a pad of celite. The filtrate was concentrated to afford a white solid (423 mg, 98% yield).

Workup

  1. filtrationThe mixture was then filtered through a pad of celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-78b5f868eeab497c8e609be12c24e9df
Source dataset
uspto-grants-2000_10
Patent number
US06131226

Reaction notes

Loading…