HCID 23286787, compound → 3-(Piperazin-1-yl)-1-azabicyclo[2.2.2]octane

Participants

Reaction Steps

A solution of 1-benzyloxy-4-(3-quinuclidinyl)piperazine (728 mg, 2.21 mmol) in methanol (5 ml). was hydrogenated at an atmospheric pressure in the presence of 10% palladium on carbon (73 mg) at room temperature for 15 h. The mixture was then filtered through a pad of celite. The filtrate was concentrated to afford a white solid (423 mg, 98% yield).

Provenance & Evidence