反应详情

13.2 g (61.6 mmol) of ethyl 2,4-dimethyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux with 39 g of Ba(OH)2.8HaO in 200 ml of water overnight. K2CO3 is added, the BaCO3 is filtered off with suction and the filtrate is extracted several times with CHCl3. The extract is dried over K2CO3 and concentrated and the residue is distilled.

1. customovernight
2. filtrationthe BaCO3 is filtered off with suction
3. extractionthe filtrate is extracted several times with CHCl3
4. dry with materialThe extract is dried over K2CO3
5. concentrationconcentrated
6. distillationthe residue is distilled