反应详情

Into a 5 L, 3 neck round bottom flask fitted with nitrogen inlet, condenser, thermometer, mechanical stirring and nitrogen outlet is added 6-bromo-1-hexanol (500 g, 2.76 mol), triphenylphosphine (768 g, 2.9 mol) and acetonitrile (1800 ml) under nitrogen. The reaction mixture is heated to reflux for 72 hrs. The reaction mixture is cooled to room temperature and transferred into a 5 L beaker. The product is recrystallized from anhydrous ethyl ether (1.5L) at 10° C. Vacuum filtration of the mixture followed by washing the white crystals with ethyl ether and drying in a vacuum oven at 50° C. for 2 hrs. gives 1140 g of the desired product.

1. customInto a 5 L, 3 neck round bottom flask fitted with nitrogen inlet, condenser
2. temperatureThe reaction mixture is heated
3. temperatureto reflux for 72 hrs
4. customThe product is recrystallized from anhydrous ethyl ether (1.5L) at 10° C
5. filtrationVacuum filtration of the mixture
6. washby washing the white crystals with ethyl ether
7. customdrying in a vacuum oven at 50° C. for 2 hrs