Hydrochloric Acid → Finafloxacin hydrochloride

HRID 367018Notes

Reaction equation

HRID 367018 reaction equation
[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@H:28]3[C@@H:23]([NH:24][CH2:25][CH2:26][O:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[ClH:30]>O>[ClH:30].[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@H:28]3[C@@H:23]([NH:24][CH2:25][CH2:26][O:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11567473Finafloxacin

Product 1

HCID 11662028Finafloxacin hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g (2.5 mmol) of 8-cyano-1-cyclopropyl-6-fluoro-7-((1S,6S)-2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is suspended in 20 ml of water, and the suspension is treated with 10 ml of 1N hydrochloric acid and stirred at room temperature for 3 hours. The precipitate obtained is filtered off with suction, washed with ethanol and dried at 80° C. in a high vacuum.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered off with suction
  3. washwashed with ethanol
  4. customdried at 80° C. in a high vacuum

Sources & evidence

ORD record
ord-de7cd314da754ab1b9b632b56aa0b068
Source dataset
uspto-grants-2000_10
Patent number
US06133260

Reaction notes

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