Hydrochloric Acid → HCID 52944870, compound

HRID 367020Notes

Reaction equation

[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@H:23]([NH:24][CH2:25][CH2:26][O:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[ClH:30]>>[ClH:30].[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@H:23]([NH:24][CH2:25][CH2:26][O:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 529448718-Cyano-1-cyclopropyl-6-fluoro-7-[(4aR,7aR)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Product 1

HCID 52944870HCID 52944870, compound

Procedure

Analogously to Example 1C, 8-cyano-1-cyclopropyl-6-fluoro-7-((1R,6R)-2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted with hydrochloric acid.

Sources & evidence

ORD record: ord-f35e14ca01b34d1d9b51fdef18ddbc1e
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133260

Reaction notes

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