Hydrochloric Acid → HCID 23287784, compound

HRID 367033Notes

Reaction equation

HRID 367033 reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:17][N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([OH:16])=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2)[CH:2]=[CH2:3].[ClH:24]>C(O)C>[ClH:24].[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:17][N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:8]([OH:16])=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15487623HCID 15487623, compound

Product 1

HCID 23287784HCID 23287784, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

61 Grams of 8-allyloxy-3,4-dihydro-5-hydroxy-6-(1-piperidinyl)methyl-2(1H)-quinolinone was suspended in 50% ethanol aqueous solution, the suspension was acidified by adding a concentrated hydrochloric acid, then crystals were precipitated immediately. Allowed to stand for a while, the crystals precipitated were collected by filtration, washed with ice-cooled ethanol and dried. The dried crystals were recrystallized from ethanol, there was obtained 40 g of 8-allyloxy-3,4-dihydro-5-hydroxy-6-(1-piperidinyl)methyl-2(1H)-quinolinone hydrochloride as pale yellow needle-like crystals.

Workup

  1. customcrystals were precipitated immediately
  2. customthe crystals precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ice-
  5. temperaturecooled ethanol
  6. customdried
  7. customThe dried crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-e7f79294d5104ad496faeaebcd4c8d3e
Source dataset
uspto-grants-2000_10
Patent number
US06133264

Reaction notes

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