反应详情

To 125 mL dichloromethane was added 3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one 3.0 g (5.92 mmol), giving a suspension. N,N-dimethyl-propanolamine 2 g (19.4 mmol) was added, and the mixture was purged with anhydrous HCl gas until saturated. After an hour at room temperature, additional N,N-dimethylethanolamine 1 g (9.69 mmol) was added, followed by stirring for 24 hours at room temperature. The mixture was evaporated in vacuo and the residue was suspended in ethyl ether. The ether suspension was washed exhaustively with 4 N NaOH, followed by water and saturated sodium chloride solution. The ether phase was dried over anhydrous magnesium sulfate, filtered, and diluted with hexane, giving a solid. Filter and dry in vacuo, giving a white solid, 1.65 g. The product was identified by 1H NMR, MS [M--H]+ =592 Da.

1. customgiving a suspension
2. customthe mixture was purged with anhydrous HCl gas until saturated
3. waitAfter an hour at room temperature
4. customThe mixture was evaporated in vacuo
5. washThe ether suspension was washed exhaustively with 4 N NaOH
6. dry with materialThe ether phase was dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. additiondiluted with hexane
9. customgiving a solid
10. filtrationFilter
11. customdry in vacuo
12. customgiving a white solid, 1.65 g