HCID 19969794, compound → HCID 19969814, compound

HRID 36704Notes

Reaction equation

HRID 36704 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([CH2:11][CH:12]([CH3:17])[CH2:13][NH:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd].C>[CH3:17][CH:12]1[CH2:11][CH:10]2[CH:15]([CH2:16][NH:8][CH2:9]2)[NH:14][CH2:13]1

Participants

5

Reactant 1

HCID 19969794HCID 19969794, compound

Product 1

HCID 19969814HCID 19969814, compound

Reagents, catalysts & solvents 3

HCID 297MethaneSolventHCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

8.0 g (35 mmol) of 8-benzyl-4-methyl-2,8-diazabicyclo[4.3.0]nonane are dissolved in 60 ml of methanol and hydrogenated over palladium on acitive charcoal at 100° C. and under 100 bar. Then the catalyst is filtered off, the filtrate is concentrated by evaporation and the residue is distilled.

Workup

  1. filtrationThen the catalyst is filtered off
  2. concentrationthe filtrate is concentrated by evaporation
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-04d979422eff4335a476900873c36cbf
Source dataset
uspto-grants-1995_05
Patent number
US05416096

Reaction notes

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