反应详情

44.3 g of 2,4-difluoroaniline are added dropwise to a solution of 115 g of ethyl 3-ethoxy-2-(2,3,4,5,6-pentafluorobenzoyl)-acrylate in 380 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 1 hour, 380 ml of water are added, while cooling with ice, and the precipitate is filtered off with suction, washed with ethanol/H2O (1:1) and dried. 135.4 g of the title compound of melting point 97°-99° C. are obtained.

1. temperaturewhile cooling with ice
2. stirringThe mixture is stirred at room temperature for 1 hour
3. temperaturewhile cooling with ice
4. filtrationthe precipitate is filtered off with suction
5. washwashed with ethanol/H2O (1:1)
6. customdried