反应详情

A mixture of 135.4 g of ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate, 20.6 g of sodium fluoride and 300 ml of anhydrous dimethylformamide is heated at 140°-150° C. for 3 hours. The suspension is poured hot onto 2 kg of ice and the precipitate is filtered off with suction, washed with water and dried. 122 g of the title compound of melting point 160°-162° C. are obtained.

1. temperatureis heated at 140°-150° C. for 3 hours
2. filtrationthe precipitate is filtered off with suction
3. washwashed with water
4. customdried