Potassium Carbonate → 3-Pyridinol, 5-ethyl-6-fluoro-

To a stirred solution of the 5-acetoxy-3-ethyl-2-fluoropyridine from Step 126e above (2.22 g, 12.1 mmol) in MeOH (50 mL) was added K2CO3 (0.84 g, 6.10 mmol). The reaction mixture was allowed to stir at room temperature 24 h. The solvent was evaporated and the residue was diluted with Et2O (100 mL) and water (100 mL). The phases were separated and the aqueous phase was neutralized (pH 7) by the addition of 1 N aqueous HCl, and extracted with diethyl ether (2×100 mL). The combined ethereal extracts were washed with brine (50 mL), dried (MgSO4), and the solvent evaporated. The crude product was purified by column chromatography (silica gel; EtOAc/hexane, 4:6) to afford the desired material as an off-white solid (1.18 g, 69%): 1H NMR (CDCl3, 300 MHz) δ 1.24 (t, J=7.5 Hz, 3H), 2.63 (q, J=7.5 Hz, 2H), 7.24 (dd, J=2.0, 5.0 Hz, 1H), 7.62 (m, 1H); MS (CI/NH3) m/z 142 (M+H)+, 159 (M+NH4)+.

1. customThe solvent was evaporated
2. additionthe residue was diluted with Et2O (100 mL) and water (100 mL)
3. customThe phases were separated
4. additionby the addition of 1 N aqueous HCl
5. extractionextracted with diethyl ether (2×100 mL)
6. washThe combined ethereal extracts were washed with brine (50 mL)
7. dry with materialdried (MgSO4)
8. customthe solvent evaporated
9. customThe crude product was purified by column chromatography (silica gel; EtOAc/hexane, 4:6)

ORD record

ord-f3ad58cef6ac4c0daa362e362e7eba44

Source dataset

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06133253