Methyl iodide → HCID 23287712, compound

HRID 367134Notes

Reaction equation

HRID 367134 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][C:6]([NH:7][C:8]2[S:9][C:10]3[N:18]=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[N:13]=2)=[CH:5][CH:4]=1.[H-].[Li+].[CH3:25]I>>[CH3:25][N:13]1[C:12](=[O:14])[C:11]2[CH:15]=[CH:16][CH:17]=[N:18][C:10]=2[S:9][C:8]1=[N:7][C:6]1[CH:19]=[CH:20][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:4][CH:5]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 62714Lithium hydrideHCID 23287724HCID 23287724, compound

Product 1

HCID 23287712HCID 23287712, compound

Procedure

The reaction procedure of Example 11 was followed except that 646 mg of 2-(4-trifluoromethylanilino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one, 18 mg of lithium hydride and 0.13 ml of methyl iodide were used. As a result, 565 mg of 3-methyl-2-[(4-trifluoromethylphenyl)imino]-2,3-dihydro-4H-pyrido[3,2-e]-1,3-thiazin-4-one was obtained as a low polarity substance, and 25 mg of 2-[N-methyl-N-(4-trifluoromethylphenyl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one was obtained as a high polarity substance.

Workup

  1. customThe reaction procedure of Example 11

Sources & evidence

ORD record
ord-716d1f71efcd46bb9785c321b34e0fbe
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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