Methyl iodide → HCID 23287687, compound

HRID 367155Notes

Reaction equation

HRID 367155 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[N:11][C:6]=2[S:5][C:4]([NH:12][C:13]2[CH:23]=[CH:22][C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][CH:14]=2)=[N:3]1.[H-].[Li+].[CH3:26]I>>[CH3:26][N:3]1[C:2](=[O:1])[C:7]2[CH:8]=[CH:9][CH:10]=[N:11][C:6]=2[S:5][C:4]1=[N:12][C:13]1[CH:23]=[CH:22][C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 62714Lithium hydrideHCID 1259240HCID 1259240, compound

Product 1

HCID 23287687HCID 23287687, compound

Procedure

The reaction procedure of Example 11 was followed except that 1.31 g of ethyl 4-[(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]benzoate, 36 mg of lithium hydride and 0.25 ml of methyl iodide were used. As a result, 656 mg of ethyl 4-[(3-methyl-4-oxo-2,3-dihydro-4H-pyrido[3,2-e]-1,3-thiazin-2-ylidene)amino]benzoate was obtained.

Workup

  1. customThe reaction procedure of Example 11

Sources & evidence

ORD record
ord-bd06dbe90c234fe29966671a459b648b
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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