Ammonium thiocyanate → HCID 23287583, compound

HRID 367163Notes

Reaction equation

HRID 367163 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH2:15]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1)[CH2:16][CH3:17]>>[CH2:15]([N:18]([C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1)[C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:26])([F:27])[F:28])=[CH:21][CH:20]=1)[CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 15666Ammonium thiocyanateHCID 27745412-Chloronicotinoyl chlorideHCID 23287697N-Propyl-4-(trifluoromethyl)aniline

Product 1

HCID 23287583HCID 23287583, compoundYield 32.5%

Procedure

The reaction procedure of Example 57 was followed except that 158 mg of 2-chloronicotinoyl chloride, 68 mg of ammonium thiocyanate and 185 mg of 4-(propylamino)benzotrifluoride were used. As a result, 106 mg of 2-[N-propyl-N-(4-trifluoromethylphenyl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one was obtained.

Workup

  1. customThe reaction procedure of Example 57

Sources & evidence

ORD record
ord-aaeabcebbc744e95957e1af4cfd82c9c
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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