Ammonium thiocyanate → HCID 57147179, compound

HRID 367166Notes

Reaction equation

HRID 367166 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH2:15]([NH:18][C:19]1[CH:29]=[CH:28][C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:21][CH:20]=1)[CH2:16][CH3:17]>>[O:5]=[C:4]1[C:3]2[CH:7]=[CH:8][CH:9]=[N:10][C:2]=2[S:11][C:12]([N:18]([C:19]2[CH:29]=[CH:28][C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:21][CH:20]=2)[CH2:15][CH2:16][CH3:17])=[N:13]1

Participants

4

Reactant 3

HCID 15666Ammonium thiocyanateHCID 27745412-Chloronicotinoyl chlorideHCID 13314418Ethyl 4-(propylamino)benzoate

Product 1

HCID 57147179HCID 57147179, compoundYield 86.9%

Procedure

The reaction procedure of Example 57 was followed except that 230 mg of 2-chloronicotinoyl chloride, 100 mg of ammonium thiocyanate and 270 mg of ethyl 4-(propylamino)benzoate were used. As a result, 418 mg of ethyl 4-[N-(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)-N-propylamino)benzoate was obtained.

Workup

  1. customThe reaction procedure of Example 57

Sources & evidence

ORD record
ord-9c852386db7549e9994339038016abe7
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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