反应详情

The reaction procedure of Example 85 was followed except that 1.733 g (11 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 880 mg of ammonium isothiocyanate, 15 ml of acetone, 1.993 g of 3,4-dimethoxy-N-ethylaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 3.388 g of 2-[N-(3,4-dimethoxyphenyl)-N-ethylaminoj-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

1. customThe reaction procedure of Example 85
2. customThe product was then recrystallized from ethanol