Ammonium thiocyanate → HCID 15485513, compound

HRID 367208Notes

Reaction equation

HRID 367208 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH3:15][NH:16][C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=1>CC(C)=O>[CH3:15][N:16]([C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1)[C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=1

Participants

5

Reactant 3

HCID 15666Ammonium thiocyanateHCID 1375052-Naphthalenamine, N-methyl-HCID 27745412-Chloronicotinoyl chloride

Product 1

HCID 15485513HCID 15485513, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The reaction procedure of Example 102 was followed except that 336 mg g of 2-chloronicotinoyl chloride, 145 mg of ammonium thiocyanate, 300 mg of 2-(methylamino)naphthalene and 7 ml of acetone were used. The product was then recrystallized from a mixture of ethanol and chloroform to obtain 321 mg of 2-[N-methyl-N-(2-naphthyl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Workup

  1. customThe reaction procedure of Example 102
  2. customThe product was then recrystallized from a mixture of ethanol and chloroform

Sources & evidence

ORD record
ord-440581e47d144b57abc319d693530eda
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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