Ammonium thiocyanate → HCID 15485514, compound

HRID 367210Notes

Reaction equation

HRID 367210 reaction equation
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH3:15][NH:16][C:17]1[CH:25]=[CH:24][C:20]2[S:21][CH:22]=[CH:23][C:19]=2[CH:18]=1>CC(C)=O>[S:21]1[CH:22]=[CH:23][C:19]2[CH:18]=[C:17]([N:16]([C:12]3[S:11][C:2]4[N:10]=[CH:9][CH:8]=[CH:7][C:3]=4[C:4](=[O:5])[N:13]=3)[CH3:15])[CH:25]=[CH:24][C:20]1=2

Participants

5

Reactant 3

HCID 15666Ammonium thiocyanateHCID 27745412-Chloronicotinoyl chlorideHCID 23287663HCID 23287663, compound

Product 1

HCID 15485514HCID 15485514, compoundYield 17.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The reaction procedure of Example 102 was followed except that 1.669 g of 2-chloronicotinoyl chloride, 722 mg of ammonium thiocyanate, 1.55 g of 5-(methylamino)benzo[b]thiophene and 35 ml of acetone were used. The product was then recrystallized from a mixture of ethanol and ethyl acetate to obtain 546 mg of 2-[N-(benzo[b]thiophen-5-yl)-N-methylamino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

Workup

  1. customThe reaction procedure of Example 102
  2. customThe product was then recrystallized from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-daac1abf1f9c4590b572235cd2275b71
Source dataset
uspto-grants-2000_10
Patent number
US06133258

Reaction notes

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