反应详情

A mixture of 2-bromopyridine-5-carboxylic acid methyl ester (1.40 g, 6.5 mmol) and piperazine (5.59 g, 65 mmol) was dissolved in acetonitrile (50 ml) and heated at reflux temperature for 2.5 h. The reaction mixture was concentrated in vacuo, dissolved in dichloromethane (50 ml) and extracted with water (3×50 ml). The organic solution was dried (MgSO4) and evaporated in vacuo, affording 0.80 g (56%) of 2-(1-piperazinyl)-5-pyridinecarboxylic acid methyl ester.

1. temperatureheated
2. temperatureat reflux temperature for 2.5 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. dissolutiondissolved in dichloromethane (50 ml)
5. extractionextracted with water (3×50 ml)
6. dry with materialThe organic solution was dried (MgSO4)
7. customevaporated in vacuo