2-Bromobenzenesulfonyl chloride → HCID 23288113, compound

HRID 367376Notes

Reaction equation

HRID 367376 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1.[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26]>>[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[C:5]([C:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=2)=[CH:6]1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 5204032-Bromobenzenesulfonyl chlorideHCID 149732095-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

Product 1

HCID 23288113HCID 23288113, compound

Procedure

(32 mg, 53%), from 5-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4b, 30.6 mg, 0.133 mmol) and 2-bromophenylsulfonyl chloride (67.9 mg, 0.27 mmol); HRMS-FAB+ for C20H19N2SO2BrF calculated MH+ : 449.03348; found: 449.03240.

Sources & evidence

ORD record
ord-f2ef83e685884817ba26a81a76ec17f1
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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