Hydrochloric Acid → HCID 23288091, compound

HRID 367384Notes

Reaction equation

HRID 367384 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:21]1([S:27]([Cl:30])(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>>[ClH:30].[CH3:1][N:2]1[CH2:3][CH:4]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:18])[F:19])[CH:15]=3)[N:10]([S:27]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:29])=[O:28])[CH:9]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 7369Benzenesulfonyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

Product 1

HCID 23288091HCID 23288091, compound

Procedure

(14.9 mg, 46%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and phenylsulfonyl chloride (18.9 mg, 0.107 mmol). HRMS-FAB+ for C21H19N2O2SF3.HCl, calculated MH+ (--HCl): 421.11975; found: 421.11923.

Sources & evidence

ORD record
ord-6379e5091beb4c659f3257ec19b0b5a7
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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