Hydrochloric Acid → HCID 23288104, compound

HRID 367386Notes

Reaction equation

HRID 367386 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:21]([C:25]1[CH:30]=[CH:29][C:28]([S:31]([Cl:34])(=[O:33])=[O:32])=[CH:27][CH:26]=1)([CH3:24])([CH3:23])[CH3:22].Cl>>[ClH:34].[C:21]([C:25]1[CH:30]=[CH:29][C:28]([S:31]([N:10]2[C:11]3[C:16](=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)(=[O:33])=[O:32])=[CH:27][CH:26]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

Product 1

HCID 23288104HCID 23288104, compound

Procedure

(8.7 mg, 24%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and 4-t-butylphenylsulfonyl chloride (24.9 mg, 0.11 mmol). HRMS-FAB+ for C25H27N2O2SF3.HCl, calculated MH+ (--HCl): 477.18237; found: 477.18134.

Sources & evidence

ORD record
ord-91b0f88c6fdb47da92efd5222a2b2c45
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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