Hydrochloric Acid → HCID 23288153, compound

HRID 367388Notes

Reaction equation

HRID 367388 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([S:29]([Cl:32])(=[O:31])=[O:30])=[CH:25][CH:24]=1.Cl>>[ClH:32].[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([S:29]([N:10]2[C:11]3[C:16](=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)(=[O:31])=[O:30])=[CH:27][CH:28]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 74014-Methoxybenzenesulfonyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

Product 1

HCID 23288153HCID 23288153, compound

Procedure

(22.2 mg, 69%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and 4-methoxyphenylsulfonyl chloride (22.1 mg, 0.107 mmol). HRMS-FAB+ for C22H21N2O3SF3.HCl, calculated MH+ : 451.13031; found: 451.13007.

Sources & evidence

ORD record
ord-6652c975ba8b466fae47941b3dcd3359
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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