Hydrochloric Acid → HCID 23288166, compound

HRID 367399Notes

Reaction equation

HRID 367399 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([F:21])([F:20])[F:19])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1.Cl>>[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([N:10]2[C:11]3[C:16](=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)=[O:28])=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 678794-Fluorobenzoyl chlorideHCID 23288118HCID 23288118, compound

Product 1

HCID 23288166HCID 23288166, compound

Procedure

(19.2 mg, 59%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethoxy-1H-indole (Example 4h, 20 mg, 0.068 mmol) and 4-fluorobenzoyl chloride (17.0 mg, 0.107 mmol), HRMS-FAB+ for C22H18N2O2F4.HCl, calculated MH (-HCl): 419.13828; found: 419.13870.

Sources & evidence

ORD record
ord-1a7f354225e04040b59d2110f82473bb
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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