Hydrochloric Acid → HCID 23288082, compound

HRID 367400Notes

Reaction equation

HRID 367400 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([F:21])([F:20])[F:19])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:22][O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1.Cl>>[CH3:22][O:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([N:10]2[C:11]3[C:16](=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)=[O:29])=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 7477p-Anisoyl chlorideHCID 23288118HCID 23288118, compound

Product 1

HCID 23288082HCID 23288082, compound

Procedure

(22.2 mg, 67%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethoxy-1H-indole (Example 4h, 20 mg, 0.068 mmol) and 4-methoxybenzoyl chloride (18.3 mg, 0.107 mmol), HRMS-FAB+ for C23H21N2O3F3.HCl, calculated MH+ (--HCl): 431.15826; found: 431.15694.

Sources & evidence

ORD record
ord-9455bec24c5646f9b70a3a1f77a8b627
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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