Hydrochloric Acid → HCID 23288085, compound

HRID 367404Notes

Reaction equation

HRID 367404 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[Cl:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[C:23]=1[C:24](Cl)=[O:25].Cl>>[Cl:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[C:23]=1[C:24]([N:10]1[C:11]2[C:16](=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=2)[C:8]([C:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=2)=[CH:9]1)=[O:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 783922,6-Dichlorobenzoyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

Product 1

HCID 23288085HCID 23288085, compound

Procedure

(25.2 mg, 78%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and 2,6 dichlorobenzoyl chloride (18.3 mg, 0.107 mmol), HRMS-FAB+ for C22H18N2OCl2F3, calculated MH+ (--HCl): 453.07483; found: 453.07779.

Sources & evidence

ORD record
ord-5f79e42c872e4064894e4e17fcad9eb6
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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